Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

نویسندگان

  • Marc G H Besselink
  • Hjalmar C van Santvoort
  • Erik Buskens
  • Marja A Boermeester
  • Harry van Goor
  • Harro M Timmerman
  • Vincent B Nieuwenhuijs
  • Thomas L Bollen
  • Bert van Ramshorst
  • Ben J M Witteman
  • Camiel Rosman
  • Rutger J Ploeg
  • Menno A Brink
  • Alexander F M Schaapherder
  • Cornelis H C Dejong
  • Peter J Wahab
  • Cees J H M van Laarhoven
  • Erwin van der Harst
  • Casper H J van Eijck
  • Miguel A Cuesta
  • Louis M A Akkermans
  • Hein G Gooszen
چکیده

Marc G H Besselink, Hjalmar C van Santvoort, Erik Buskens, Marja A Boermeester, Harry van Goor, Harro M Timmerman, Vincent B Nieuwenhuijs, Thomas L Bollen, Bert van Ramshorst, Ben J M Witteman, Camiel Rosman, Rutger J Ploeg, Menno A Brink, Alexander F M Schaapherder, Cornelis H C Dejong, Peter J Wahab, Cees J H M van Laarhoven, Erwin van der Harst, Casper H J van Eijck, Miguel A Cuesta, Louis M A Akkermans, Hein G Gooszen, for the Dutch Acute Pancreatitis Study Group

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منابع مشابه

Expression of concern--Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial.

BACKGROUND Infectious complications and associated mortality are a major concern in acute pancreatitis. Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce. Our aim was to assess the effects of probiotic prophylaxis in patients with predicted severe acute pancreatitis. METHODS In this multicenter randomized, double-blind, placebo-cont...

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Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial [ISRCTN38327949]

BACKGROUND Infectious complications are the major cause of death in acute pancreatitis. Small bowel bacterial overgrowth and subsequent bacterial translocation are held responsible for the vast majority of these infections. Goal of this study is to determine whether selected probiotics are capable of preventing infectious complications without the disadvantages of antibiotic prophylaxis; antibi...

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Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis.

BACKGROUND Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS We conducted a randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in patients with pr...

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Role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis: a double-blind randomized controlled trial.

GOALS To study the role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis (AP). BACKGROUND Bacterial translocation has been implicated in infective complications in AP, which has been shown to be prevented by probiotics. STUDY A double-blind, randomized placebo-controlled trial was conducted. Consecutive patients with AP presenting within 72 hours after t...

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Acute Pancreatitis Randomized Controlled Studies

Abou-Assi S, Craig K, O’Keefe SJ: Hypocaloric jejunal feeding is better than total parenteral nutrition in acute pancreatitis: Results of a randomized comparative study. Am J Gastroenterol 2002;97:2255–2262. Bassi C, Falconi M, Talamini G, Uomo G, Papaccio G, Dervenis C, Salvia R, Minelli EB, Pederzoli P: Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis. Gast...

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تاریخ انتشار 2008